Literaturverzeichnis von Prof. Dr. Schirren

Originalarbeiten als Erst- oder Letztautor:

1. Schirren CA, Völpel H and Meuer SC. Adhesion molecules on freshly recovered T leukemias promotes tumor directed lympholysis. Blood 1992; 79:138-143.

2. Schirren CA, Völpel H and Meuer SC. Spontaneous responsiveness to cytokines by human T cell leukemias. Leukemia 1992; 6:574-581.

3. Schirren CA, Völpel H and Meuer SC. Cytokines and adhesion receptors in immune responses against tumours. J Irish Col of Physicians and Surgeons 1993; 22 Suppl.1:33-37.

4. Schirren CA, Völpel H, Hoffmann JC, Henning SW, Qiao L, Autschbach F, Dengler TJ, Döhner H and Meuer SC. Biological response modifiers render tumor cells susceptible to autologous effector mechanism by influencing adhesion receptors. Leukemia and Lymphoma 1993; 10:25-33.

5. Schirren CA, Zachoval R, Schirren CG, Gerbes AL and Pape GR. A role for chronic hepatitis C virus infection in a patient with cutaneous vasculitis, cryoglobulinemia, and chronic liver disease: effective treatment with interferon-a. Dig Dis Sci 1995; 40:1221-1225.

6. Schirren CA, Jung MC, Zachoval R, Diepolder H, Hoffmann R, Riethmüller G and Pape GR. Analysis of T cell activation pathways in patients with liver cirrhosis, delayed hypersensitivity and other T cell dependent functions. Clin Exp Immunol 1997; 108:144-150

7. Schirren CA, Berghaus TM and Sackmann M. Thrombotic thrombocytopenic purpura (TTP) following ecstasy induced liver failure. Annals of Internal Medicine 1999; 130: 163.

8. Schirren CA, Jung MC, Worzfeld T, Mamin M, Baretton GB, Gruener NH, Gerlach JT, HM Diepolder, R Zachoval, and GR Pape. Cytokine profile of liver- and blood-derived nonspecific T cells after liver transplantation: T helper cells type 1/0 lymphokines dominates in recurrent HCV-infection and rejection. Liver Transplantation 2000; 6: 222-8.

9. Schirren CA, Baretton G, Interdisciplinary Liver Transplantation Group. Nefadozone-induced acute liver failure. Am J Gastroenterol 2000; 95: 10-11.

10. Schirren CA, Jung MC, Gerlach TJ, Worzfeld T, Baretton GB, Mamin M, Gruener NH, Houghton M, Pape GR. Liver-derived hepatitis C virus-specific CD4+ T cells recognize multiple HCV-epitopes and produce IFN-gamma. Hepatology 2000; 32: 597-603

11. Schirren CA, Jung MC, Worzfeld T, Mamin M, Baretton GB, Gerlach TJ, Gruener NH, Zachoval R, Houghton M, Rau HG, Pape GR. Hepatitis C virus-specific CD4+ T cell response after liver transplantation occurs early, is multispecific, compartmentalize to the liver, and does not correlate with recurrent disease. J Infect Dis 2001; 183: 1187-94.

12.Schirren CA, Zachoval R, Baretton G, Gerlach JT, Ulsenheimer A, Gruener NH, Diepolder HM, Schraut W, Rau HG, Nitschko H, Pape GR, Jung MC. Antiviral treatment of recurrent Hepatitis C Virus (HCV) infection after liver transplantation: Association of a strong, multispecific, and longlasting CD4+ T cell response with HCV elimination. J Hepatol 2003;39: 397-404.

13.Gruener NH, Ulsenheimer A, Jung MC, Gerlach JT, Zachoval R, Diepolder HM, Baretton G, Schauer R, Pape GR, Schirren CA. Analysis of a successful HCV-specific CD8+ T cells response in patients with recurrent HCV-infection after liver transplantation (OLTX). Liver Transplantation 2004;10: 1487-1496.

14.Gruener NH, Jung MC, Schirren CA. Recurrent hepatitis C virus infection after liver transplantation: natural course, therapeutic approach and possible mechanisms of viral control. J Antimicrob Chemother. 2004;54:17-20.

Originalarbeiten als Koautor:

1. Lankisch PG, Schirren CA, Schmidt H, Schönfelder G and Creutzfeldt W. Etiology and incidence of acute pancreatitis: A 20-year study in a single institution. Digestion 1989; 44:20-25.

2. Lankisch PG, Otto J, Löhr A, Schirren CA and Schuster R. Pancreatic calcification in patients with normal pancreatic function. Int J Pancreatol 1989; 5:281-293.

3. Lankisch PG, Schirren CA, Otto J. Methemalbumin in acute pancreatitis: An evaluation of its prognostic value and comparison with multiple prognostic parameters. Am J Gastroenterol 1989; 84:1391-1395.

4. Lankisch PG and Schirren CA. Increased body weight as a prognostic parameter in the course of acute pancreatitis. Pancreas 1990; 5:626-629.

5. Lankisch PG, Schirren CA, Kunze E. Undetected fatal acute pancreatitis: Why is the disease so frequently overlooked? Am J Gastroenterol 1991; 86:322-326.

6. Schraven B, Schirren CA, Kirchgessner H, Siebert B and Meuer SC. Four CD45/P56lck- associated phosphorproteins (pp29-pp32) undergo alterations in human T cell activation. Eur J Immunol 1992; 22:1857-1863.

7. Lankisch PG, Burchard-Reckert S, Petersen M, Lehnick D, Schirren CA, Köhler H, Stöckmann F, Peiper HJ and Creutzfeldt W. Morbidity and mortality in 602 patients with acute pancreatitis seen between the years 1980-1994. Z Gastroenterol 1996; 34:371-377.

8. Lankisch PG, Burchard-Reckert S, Petersen M, Lehnick D, Schirren CA, Stöckmann F and Köhler H. Etiology and age have only limited influence on the course of acute pankreatitis. Pancreas 1996; 13:344-349.

9. Diepolder HM, Jung MC, Keller E, Schraut W, Gerlach JT, Grüner N, Zachoval R, Hoffmann RM, Schirren CA, Scholz S, and Pape GR. A vigorous virus-specific CD4+ T cell response may contribute to the association of HLA-DR13 with viral clearance in hepatitis B. Clin Exp Immunol 1998; 113:244-251.

10. Gerlach JT, Diepolder HM, Jung MC, Gruener NH, Schraut WW, Zachoval R, Hoffmann R, Schirren CA, Santantonio T, Pape GR. Recurrence of hepatitis C virus after loss of virus-specific CD4(+) T-cell response in acute hepatitis C. Gastroenterology 1999;117:933-941.

11. Gerlach JT, Diepolder HM, Jung MC, Gruener NH, Zachoval R, Schirren CA, Hoffmann R, Schraut WW, Waechtler M, Eichenlaub D, Pape GR. Akute Hepatitis C. Deutsches Ärzteblatt 1999;96:3103-3106.

12. Gruener NH, Gerlach JT, Jung MC, Diepolder HM, Schirren CA, Schraut WW, Hoffmann R, Zachoval R, Santantonio T, Cucchiarini M, Cerny A, Pape GR. Association of HCV-specific CD8+ T cells with viral clearance in acute hepatitis C. J Infect Dis 2000; 181: 1528-36.

13. Ehrentraut S, Rothenhausler HB, Gerbes AL, Rau HG, Thiel M, Schirren CA, Kapfhammer HP. Akutes Leberversagen unter Nefazodon-Therapie? Ein Fallbericht. Nervenarzt 2002;73:686-689.

14. Mori K, Scheidler J, Helmberger T, Holzknecht N, Schauer R, Schirren CA, Bittmann I, Dugas M, Reiser M. Detection of malignant hepatic lesions before orthotopic liver transplantation: accuracy of ferumoxides-enhanced MR imaging. AJR Am J Roentgenol 2002;179:1045-1051.

15. Gruener NH, Jung MC, Ulsenheimer A, Gerlach TJ, Diepolder HM, Schirren CA, Hoffmann R, et al. Hepatitis C virus eradication associated with hepatitis B virus superinfection and development of a hepatitis B virus specific T cell response. J Hepatol. 2002;37:866-869.

16. Ulsenheimer A, Gerlach JT, Gruener NH, , Jung MC, Schirren CA, Schraut W, Zachoval R, Pape GR, Diepolder HM. Detection of functionally altered hepatitis C virus-specific CD4+ T cells in acute and chronic hepatitis C. Hepatology 2003; 37: 1189-98.

17. Jung MC, Gruner N, Zachoval R, Schraut W, Gerlach T, Diepolder H, Schirren CA, et al. Immunological monitoring during therapeutic vaccination as a prerequisite for the design of new effective therapies: induction of a vaccine-specific CD4+ T-cell proliferative response in chronic hepatitis B carriers. Vaccine. 2002;20:3598-3612.

18. Gerlach JT, Diepolder HM, Zachoval R, Gruener NH, Jung MC, Ulsenheimer A, Schraut WW, Schirren CA, Waechtler M, Backmund M, Pape GR. Acute Hepatitis C: High rate of both spontaneous and treatment induced viral clearance. Gastroenterology 2003; 125: 80-88

19.Ulsenheimer A, Gerlach JT, Jung MC, Gruener N, Wachtler M, Backmund M, Santantonio T, Schraut W, Heeg MH, Schirren CA, Zachoval R, Pape GR, Diepolder HM. Plasmacytoid dendritic cells in acute and chronic hepatitis C virus infection. Hepatology. 2005;41:643-651.

20.Gerlach JT, Ulsenheimer A, Gruner NH, Jung MC, Schraut W, Schirren CA, Heeg M, Scholz S, Witter K, Zahn R, Vogler A, Zachoval R, Pape GR, Diepolder HM. Minimal T-cell-stimulatory sequences and spectrum of HLA restriction of immunodominant CD4+ T-cell epitopes within hepatitis C virus NS3 and NS4 proteins. J Virol. 2005;79:12425-12433.

21.Schonermarck U, Schirren CA, Mistry-Burchardi N, Weiss M, Eichhorn P, Samtleben W. Interstitial nephritis and high titers of PR3-ANCA: an unusual manifestation of ANCA-associated disease. Clin Nephrol. 2005;64:383-386.

22.Raziorrouh B, Jung MC, Schirren CA, Loehe F, Thiel M, Nitschko H, Diepolder H, Ulsenheimer A, Heeg M, Zachoval R, Gruener NH. Antiviral therapy for recurrent hepatitis C after liver transplantation: sustained virologic response is related to genotyp 2/3 and response at week 12. Eur J Gastroenterol Hepatol. 2008; 20 (8): 778-83V.

Buchbeiträge und Übersichtsarbeiten

1. Schirren CA, Völpel, H. and Meuer, S.C. Adhesion molecules and their possible role on immune surveillance. Berlin, Heidelberg, New York, London, Paris, Tokyo, Hong Kong, Barcelona, Budapest:Springer Verlag, 1992. pp. 101-112.

2. Qiao L, Schürmann G, Meuer SC, Wallich R, Schirren CA, and Autschbach F. Regulation of T cell reactivities by intestinal mucosa. In: Advances in Mucosal Immunology, edited by Mestecky J., New York: Plenum Press, 1995, p. 31-34.

3. Schirren CA. Alkoholbedingte Lebererkrankungen. Münch Med Wschr 1996; 138:172-176.

4. Schirren CA. Akutes Leberversagen. Hepatologie für die Praxis. Herausgeber: Pape GR, Göke B. Elsevier GmbH, Urban und Fischer 2006;175-182.

Abstracts

1. Lankisch PG, Otto J, Löhr A, Schirren CA and Schuster R. Pancreatic calcification do not indicate exocrine pancreatic insufficiency. Int J Pancreatol 1988; 3, Suppl.2:258. (Abstract)

2. Lankisch PG, Schirren CA, Schmidt H, Schönfelder G and Creutzfeldt W. Acute pancreatitis: A disease with increasing incidence in a changing pattern of etiology. Digestion 1988; 40:94. (Abstract)

3. Lankisch PG, Schirren CA and Otto J. Acute pancreatitis in elderly patients does not have a bad prognosis. Int J Pancreatol 1988; 3, Suppl.2:258. (Abstract)

4. Lankisch PG and Schirren CA. Increased body weight: A new prognostic factor for the course of acute pancreatitis. Int J Pancreatol 1988; 3, Suppl.2:258. (Abstract)

5. Lankisch PG, Schirren CA and Otto J. Methämalbumin bei akuter Pankreatitis: Ein Vergleich der Aussagefähigkeit eines einzelnen gegenüber multiplen prognostischen Faktoren (Ranson) für die Prognose der Erkrankung. Klin Wochenschr 1989; 67, Suppl. 16:238. (Abstract)

6. Lankisch PG and Schirren CA. Undetected acute pancreatitis. Digestion 1989; 43:155. (Abstract)

7. Lankisch PG, Schirren CA and Otto J. Methaemalbumin in acute pancreatitis: an evaluation of a single versis multiple prognostic parameters (Ransonts signs) for the course of the disease. Digestion 1989; 43:155. (Abstract)

8. Schirren CA, Schraven B and Meuer SC. Expression of unusual CD45 forms of freshly recovered human T leukemias. Tagung der Gesellschaft für Immunologie 1992; (Abstract)

9. Schirren CA, Volpel H, Meuer SC. Die Expression von Adhäsionsmolekülen auf frisch gewonnenen humanen T-Zell-Leukämien und ihre pathophysiologische Bedeutung für die autologe tumorspezifische Lympholyse. Klin Wochenschr 1992;69:23.

10. Schirren CA, Zachoval R, Schirren CG, Gerbes AL and Pape GR. A role for chronic hepatitis C virus-infection in a patient with cutaneous vasculitis, cryoglobulinemia, and chronic liver disease: Effective therapy with a biological immune-modifier. Z Gastroenterol 1994; 32:71. (Abstract)

11. Buchard-Reckert S, Petersen M, Schirren CA, Stöckmann F, Köhler H and Lankisch PG. Neither age nor aetiology are decisive for the prognosis of acute pancreatitis. Gut 1995; 37 (Suppl.2):A137. (Abstract)

12. Schirren CA, Diepolder H, Zachoval R, Jung MC, Riethmüller G and Pape GR. Funktion von T-Lymphozyten und Monozyten bei Patienten mit äthyltoxischer Leberzirrhose: Wo liegt der Immundefekt? Z Gastroenterol 1995; 33:70. (Abstract)

13. Jung MC, Gerlach JT, Hoffmann RM, Schirren CA, Zachoval R, Diepolder H, Pape GR and Interdisziplinäre Lebertransplantationsgruppe. Toleranz der virusspezifischen CD4+ T-Zellantwort bei Patienten mit HBV oder HCV Reinfektion nach Lebertransplantation. Deutsche Transplantationsgesellschaft in München 1996; (Abstract)

14. Lankisch PG, Burchard-Reckert S, Petersen M, Lehnick D, Schirren CA, Köhler H, Stöckmann F, Peiper HJ and Creutzfeldt W. Morbidity and mortality in acute pankreatitis: an update. Gastroenterol 1996; 110 (Suppl):A409. (Abstract)

15. Lankisch PG, Burchard-Reckert S, Petersen M, Lehnick D, Schirren CA, Köhler H, Stöckmann F, Peiper HJ and Creutzfeldt W. Morbidity and mortality in acute pancreatitis: an update. Digestion 1996; 57:243. (Abstract)

16. Schirren CA, Zachoval R, Diepolder H, Jung MC, Hoffmann R and Pape GR. Analysis of T cell activation pathways in patients with alcoholic liver cirrhosis who have impaired T cell dependent functions. Hepatology 1996; 24:574A. (Abstract)

17. Jung MC, Gerlach JT, Hoffmann RM, Schirren CA, Zachoval R, Diepolder H, Pape GR und Interdisziplinäre Lebertransplantations-gruppe. Toleranz der virusspezifischen CD4+ T-Zellantwort bei Patienten mit HBV oder HCV Reinfektion nach Lebertransplantation. Z Gastroenterol 1997; 35:80. (Abstract)

18. Schirren CA, Jung MC, Mamin M, Hoffmann RM, Gerlach JT, Diepolder HM, Zachoval R, Houghton M and Pape GR. Intrahepatic T cells from hepatitis C virus-reinfected liver transplants are multispecific and produce gamma-interferon. Hepatology 1997; 26:153A. (Abstract)

19. Diepolder HM, Jung MC, Keller E, Gerlach JT, Schraut W, Zachoval R, Hoffmann RM, Scholz S, Grüner NH, Schirren CA and Pape GR. The association of HLA-DR13 with viral clearance in hepatitis B virus infection may be mediated by a more vigorous virusspecific HLA class II restricted T cell response. Hepatology 1997; 26:223A.

20. Gerlach JT, Diepolder HM, Grüner N, Jung MC, Zachoval R, Hoffmann R, Schirren CA, Schraut W, Wächtler M, Houghton M, and Pape GR. Acute hepatitis C: viral elimination depends on virusspecific CD4+ T cells. Hepatology 1997; 26:405A.

21. Jung MC, Gerlach JT, Hoffmann RM, Schirren CA, Zachoval R, Diepolder H, Pape GR and Interdisziplinäre Lebertransplantations-gruppe. Toleranz der virusspezifischen CD4+ T-Zellantwort bei Patienten mit HBV oder HCV Reinfektion nach Lebertransplantation. Z Gastroenterol 1997; 35:80.(Abstract)

22. Jung MC, Gerlach JT, Hoffmann RM, Schirren CA, Zachoval R, Diepolder HM, Houghton M, Grüner N, Pape GR and the liver transplantation group. Characterization of the hepatitis B und hepatitis C virus-specific CD4+ T cell response in recurrent hepatitis after liver transplantation. Hepatology 1997; 26:153A.

23. Gerlach JT, Diepolder HM, Grüner NH, Jung MC, Zachoval R, Hoffmann R, Schirren CA, Schraut W, Santantonio T, Houghton M and Pape GR. Recurrence of hepatitis C virus after loss of virus specific CD4+ T cell response in acute hepatitis C. J Hepatol 1998; 28:44.(Abstract)

24. Gerlach JT, Kullig G, Grüner NH, Diepolder HM, Jung MC, Zachoval R, Hoffmann R, Schirren CA, Schraut W, Porst H and Pape GR. Maintenance of a virus specific helper T cell response 20 years after infection with one strain of HCV in healthy individuals. J Hepatol 1998; 28:51.(Abstract)

25. Gerlach JT, Diepolder HM, Grüner NH, Jung MC, Zachoval R, Hoffmann R, Schirren CA, Schraut W, Wächtler M, Houghton M and Pape GR. Akute Hepatitis C: Die Viruselimination hängt von HCV spezifischen CD4+ T-Lymphozyten ab. Z. Gastroenterol. 1998; 36:84.

26. Schirren CA, Jung MC, Mamin M, Worzfeld T, Hoffmann RM, Gerlach JT, Diepolder HM, Zachoval R, Houghton M, and Pape GR. Virusspezifische CD4+ T-Zellen im HCV reinfizierten Lebertransplantat erkennen multiple HCV-Proteine. Z. Gastroenterol. 1998. 36:90.

27. Schirren CA, Jung MC, Worzfeld T, Mamin M, Gerlach JT, Grüner N, Hoffmann RM, Diepolder HM, Zachoval R, Houghton M, and Pape GR. Response of T cells from HCV reinfected grafts after Ltx resembles that of T cells from peripheral blood in acute hepatitis C. J Hepatol 1998; 28:43.(Abstract)

28. Schirren CA, Jung MC, Worzfeld T, Mamin M, Gerlach JT, Grüner N, Diepolder HM, Zachoval R, Houghton M, and Pape GR. T cells from HCV reinfected grafts after Ltx recognize preferably non-structural HCV-proteins and produce gamma-IFN. Digestion 1998; 59 (suppl 3):31.(Abstract)

29. Grüner N, Gerlach JT, Jung MC, Diepolder HM, Zachoval R, Hoffmann R, Schraut W, Schirren CA, Santantonio T, and Pape GR. Association of HCV-specific g-Interferon producing CD8+ T cells with viral clearance in acute hepatitis C. Hepatology 1998; 28:330A

30. Schirren CA, Jung MC, Worzfeld T, Mamin M, Gerlach JT, Grüner N, Diepolder HM, Zachoval R, Houghton M, and Pape GR. Recurrent HCV-infection of the liver: HCV-specific T cell comparmentalize to liver, recognize multiple HCV-proteins, and display a TH1/0 lymphokine profile. Hepatology 1998; 28:332A.

31. Gerlach JT, Diepolder HM, Gruener NH, Jung MC, Zachoval R, Hoffmann R, Schirren CA, Schraut W, Wächtler M, Houghton M, Pape GR. Akute Hepatitis C: Die Viruselimination hängt von HCV spezifischen CD4+ T-Lymphozyten ab. Z Gastroenterol 1998;36:84.

32. Schirren CA, Jung MC, Worzfeld T, Mamin M, Gerlach JT, Gruener N, Hoffmann RM, Diepolder HM, Zachoval R, Houghton M, Pape GR. Response of T cells from HCV reinfected grafts after Ltx resembles that of T cells from peripheral blood in acute hepatitis C. J Hepatol 1998;28:43.

33. Schirren CA, Jung MC, Mamin M, Worzfeld T, Hoffmann RM, Gerlach JT, Diepolder HM, Zachoval R, Houghton M, Pape GR. Virusspezifische CD4+ T-Zellen im HCV reinfizierten Lebertransplantat erkennen multiple HCV-Proteine. Z Gastroenterol 1998;36:90.

34. Gerlach JT, Diepolder HM, Gruener NH, Jung MC, Zachoval R, Hoffmann R, Schirren CA, Pape GR. Symptomatic acute hepatitis C: When to treat? Hepatology 1999;30:195A.

35. Jung MC, Zachoval R, Gruener NH, Schirren CA, Gerlach TJ, Hoffmanm R, Diepolder HM, Pape GR. Increase in gamma-interferon producing Cells by lamivudine treatment of patients with chronic hepatitis B after liver transplantation. Hepatology 1999;30:325A.

36. Gerlach JT, Diepolder HM, Gruener NH, Jung MC, Zachoval R, Hoffmann R, Schirren CA, Schraut W, Pape GR. Natural course of symptomatic acute hepatitis C. J Hepatol 1999;30:120.

37. Gruener NH, Gerlach JT, Jung MC, Diepolder HM, Zachoval R, Hoffmann R, Schraut WA, Schirren CA, Sanantonio I, Pape GR. HCV-specific g-interferon producing CD8+ T cells contribute to viral clearance in acute hepatitis C. J Hepatol 1999;30:108.

38. Gruener NH, Schirren CA, Gerlach JT, Jung MC, Diepolder HM, Zachoval R, Hoffmann R, Schraut WA, Pape GR. Patients with recurrent HCV infection after liver transplantation mount a virusspecific CD8+ T cell response despite immunosuppression. J Hepatol 1999;30:110

39. Schirren CA, Jung MC, Worzfeld T, Mamin M, Baretton GB, Gerlach TJ, Gruener NH, Diepolder HM, Zachoval R, Houghton M, Pape GR. Recurrent HCV-infection after liver transplantation: HCV-specific CD4+T cells response is characterized by an early and strong onset within 6 months after transplantation. Z Gastroenterol 1999;37:1041.

40. Schirren CA, Jung MC, Worzfeld T, Gerlach TJ, Gruener NH, Diepolder HM, Houghton M, Zachoval R, Pape GR. CD4+ T cell response in patients with chronic hepatitis C and HCV-associated liver cirrhosis is multispecific and can be detected in different compartments. Hepatology 1999;30:352A.

41. Hiller E, Schauer R, Roth U, Salat C, Schirren CA. Successfull correction of the phenotypic expression of a patient with congenital factor II deficiency by orthotopic liver transplantation (OLT). Blood 1999; 94: Suppl. 1; 96b.

42. Schirren CA, Jung MC, Worzfeld T, Gerlach TJ, Gruener NH, Diepolder HM, Houghton M, Pape GR. Intrahepatic HCV-specific CD4+ T cells in chronic HCV-infection are multispecific and produce g-IFN. J Hepatol 2000; 32: Suppl. 2; 33.

43. Gruener NH, Jung MC, Diepolder HM, Gerlach JT, Zachoval R, Schraut WA, Schirren CA, Santantonio T, Pape GR. Correlation of the CD8+ and CD4+ T cell response during spontaneous clearance of hepatitis C virus. J Hepatol 2000;32: Suppl. 2; 89

44.Schirren CA, Zachoval R, Jung MC, Gerlach JT, Gruener NH, Diepolder HM, Houghton M, Rau HG, Pape GR. Only a strong, multispecific,and longlasting CD4+ T cell response is associated with viral elimination in patients with recurrent HCV-infection after OLTx. J. Hepatol. 2001;34:114.

45.Schirren CA, Gruener NH, Jung MC, Zachoval R, Gerlach JT, Diepolder HM, Houghton M, Rau HG, Pape GR. Hepatitis C virus (HCV)-specific CD8+ T cells in patients with recurrent HCV-infection ofter liver transplantation (OLTx). J. Hepatol. 2001;34:115.

46.Jung MC, Gruener N, Zachoval R, Schraut W, Gerlach T, Diepolder H, Schirren CA, Page M, Trojan J, Zeuzem S, Pape GR. Therapeutic vaccination in chronic Hepatitis B: Qualitative and quantitative analysis of the virusspecific immune response. J. Hepatol. 2001;34:16.

47.Gerlach JT, Zachoval R, Gruener NH, Jung MC, Ulsenheimer A, Schraut W, Schirren CA, Waechtler M, Backmund M, Diepolder HM, Pape GR. Acute hepatitis C: Natural course and response to antiviral treatment. Hepatology 2001;34:341.

48.Zachoval R, Schirren CA, Matthias B, Diepolder HM, Gerlach JT, Gruener NH, Jung MC, Pape GR. Interferon/ribavirin combination therapy in patients with hepatitis C reactivation after liver transplantation. J. Hepatol. 2001;34:34

49.Gruener NH, Diepolder HM, Brotman B, Jung MC, Gerlach JT, Zachoval R, Schraut W, Schirren CA, Ulsenheimer A, Prince AM, Pape GR. Treatment of two chronically HCV infected chimpanzees with protein/peptide pulsed autologous dendritic cells. Abstract band of 8th international symposium on HCV and related viruses 2001:219.

50.Gruener NH, Lechner F, Jung MC, Diepolder HM, Gerlach JT, Zachoval R, Schraut W, Schirren CA, Ulsenheimer A, Klenerman P, Pape GR. Fehlende Effektorfunktion HCV spezifischer CD8+ T Lymphozyten bei akuter Hepatitis C als möglicher Mechanismus der Chronifizierung. Z Gastroenterol 2001;39:114.

51.Gerlach JT, Zachoval R, Gruener NH, Jung MC, Ulsenheimer A, Schraut W, Schirren CA, Waechtler M, Backmund M, Diepolder HM, Pape GR. Acute hepatitis C: High rate of both spontaneous and treatment induced viral clearance in symptomatic patients. Abstract band of 8th international symposium on HCV and related viruses 2001:301.

52.Gerlach JT, Zachoval R, Gruener NH, Jung MC, Ulsenheimer A, Schraut W, Schirren CA, Waechtler M, Backmund M, Diepolder HM, Pape GR. Acute hepatitis C: Natural course and response to antiviral treatment. Hepatology 2001;34:341.

53.Diepolder H, Gerlach JT, Gruener N, Ulsenheimer A, Jung MC, Zachoval R, Schirren CA, Schraut W, Santantonio T, Pape GR. Detection of functionally impaired hepatitis C virus specific CD4+ T cells in acute and chronic hepatitis C. Abstract band of 9th international symposium on HCV and related viruses 2002:169.

54.Diepolder HM, Gerlach JT, Gruener N, Ulsenheimer A, Jung MC, Zachoval R, Schirren CA, Schraut W, Pape GR. Detection of functionally altered hepatitis C virus specific CD4+ T cells in acute and chronic hepatitis C. Hepatology 2002;36:544A.

53.Schirren CA, Gruener NH, Ulsenheimer A, Jung MC, Gerlach JT, Zachoval R, Diepolder HM, Baretton G, Schauer R, Pape GR. HCV-specific CD8+ T cells are detectable in patients with recurrent HCV-infection after liver transplantation (OLTX): Achievement of HCV eradication under antiviral treatment is associated with a strong, multispecific CD8+ T cell response. Hepatology 2002;36:220A.

54.Gruener NH, Gerlach JT, Ulsenheimer A, Diepolder H, Wierenga E, Zachoval R, Schirren CA, Pape GR, Jung MC. Naturally occurring HBV variants within the nucleocapsid protein create null ligand peptides unable to activate HBV-specific CD4+ T lymphocytes. Hepatology 2003;38:252A.

55.Ulsenheimer A, Gruener NH, Jung MC, Gerlach JT, Zachoval R, Schraut W, Schirren CA, Pape GR, Diepolder HM. Reduced interferon-alpha production by plasmacytoid dendritic cells in acute viral hepatitis B and C. Hepatology 2003;38:362A.

56.Gerlach JT, Ulsenheimer A, Gruener N, Zachoval R, Jung MC, Schraut W, Schirren CA, Wachtler M, Backmund M, Pape GR, Diepolder H. Characterization of novel CD4+ T cell epitopes in acute selflimited HCV infection. Hepatology 2003;38:172A.

57.Gruener NH, Ulsenheimer A, Jung MC, Gerlach JT, Zachoval R, Diepolder HM, Baretton G, Schauer R, Pape GR, Schirren CA. Analysis of a successfull HCV-specific CD8+ T cell response in patients with recurrent HCV-infection after liver transplantation (OLTx). Journal of Hepatology 2004;40:6.

58.Gerlach JT, Ulsenheimer A, Gruener N, Zachoval R, Jung MC, Schirren CA, Waechtler M, Backmund M, Pape GR, Diepolder H. Charakterisierung immundominanter CD4+ T-Zellepitope bei Patienten mit selbstlimitierter akuter Hepatitis C. Z Gastroenterol 2004;42:47.

59.Ulsenheimer A, Jung MC, Gerlach JT, Gruener NH, Schirren CA, Waechtler M, Backmund M, Schraut W, Zachoval R, Pape GR, Diepolder HM. Impaired interferon-alpha production by plasmacytoid dendritic cells. Journal of Hepatology 2004;40:124.

60.Ulsenheimer A, Gruener NH, Jung MC, Gerlach JT, Zachoval R, Schraut W, Schirren CA, Waechtler M, Backmund M, Pape GR, Diepolder H. Verminderte Interferon-alpha Produktion plasmacytoider dendritischer Zellen bei Patienten mit akuter HBV und HCV Infektion. Z Gastroenterol 2004;42:47.

61.Ulsenheimer A, Jung MC, Gerlach JT, Gruener NH, Schirren CA, Waechtler M, Backmund M, Schraut W, Zachoval R, Pape GR, Diepolder HM. 2004 Impaired interferon-alpha production by plasmacytoid dendritic cells. J Hepatol. 2004;40.

62.Ulsenheimer A, Gerlach JT, Gruener NH, Jung MC, Schraut W, Schirren CA, Scholz S, Zachoval R, Pape GR, Diepolder HM. Minimal T cell stimulatory sequences and spectrum of HLA restriction of immundominant CD4+ T cell epitopes within hepatitis C virus NS3 and NS4. Abstract band of 11th international symposium on HCV and related viruses 2004:203.

Vorträge auf nationalen und internationalen Kongressen

1. Vortrag auf der 98. Tagung der Deutschen Gesellschaft für Innere Medizin in Wiesbaden 1992:
Schirren CA, Volpel H, Meuer SC. Die Expression von Adhäsionsmolekülen auf frisch gewonnenen humanen T-Zell-Leukämien und ihre pathophysiologische Bedeutung für die autologe tumorspezifische Lympholyse. Klin Wochenschr 1992;69:23.

2. Vortrag auf der Tagung der „European Association for the Study of Liver Disease“ in Lissabon 1998:
Schirren CA, Jung MC, Worzfeld T, Mamin M, Gerlach JT, Grüner N, Hoffmann RM, Diepolder HM, Zachoval R, Houghton M, Pape GR. Response of T cells from HCV reinfected grafts after Ltx resembles that of T cells from peripheral blood in acute hepatitis C. J Hepatol 1998;28:43.

3. Vortrag auf der Tagung der „German Association for the Study of Liver Disease“ in Halle 1998:
Schirren CA, Jung MC, Mamin M, Worzfeld T, Hoffmann RM, Gerlach JT, Diepolder HM, Zachoval R, Houghton M, Pape GR. Virusspezifische CD4+ T-Zellen im HCV reinfizierten Lebertransplantat erkennen multiple HCV-Proteine. Z Gastroenterol 1998;36:90.

4. Vortrag auf der Tagung des „World Congress of Gastroenterology“ in Wien 1998:
Schirren CA, Jung MC, Worzfeld T, Mamin M, Gerlach JT, Grüner N, Diepolder HM, Zachoval R, Houghton M, Pape GR. T cells from HCV reinfected grafts after Ltx recognize preferably non-structural HCV-proteins and produce gamma-IFN. Digestion 1998;59 (suppl 3):31.

5. Vortrag auf der „VI international conference on current trends in chronically evolving viral hepatitis“ in Hannover 1999:
Schirren CA, Jung MC, Worzfeld T, Mamin M, Baretton GB, Gerlach TJ, Gruener NH, Diepolder HM, Zachoval R, Houghton M, Pape GR. Recurrent HCV-infection after liver transplantation: HCV-specific CD4+T cells response is characterized by an early and strong onset within 6 months after transplantation. Z Gastroenterol 1999;37:1041.

6. Vortrag auf der Tagung der „European Association for the Study of Liver Disease“ in Rotterdam 2000:
Schirren CA, Jung MC, Worzfeld T, Gerlach TJ, Gruener NH, Diepolder HM, Houghton M, Pape GR. Intrahepatic HCV-specific CD4+ T cells in chronic HCV-infection are multispecific and produce g-IFN. J Hepatol 2000; 32; Suppl.2: 33

7. Vortrag auf der Tagung der „American Association for the Study of Liver Disease“ in Boston 2002:
Schirren CA, Gruener NH, Ulsenheimer A, Jung MC, Gerlach JT, Zachoval R, Diepolder HM, Baretton G, Schauer R, Pape GR. HCV-specific CD8+ T cells are detectable in patients with recurrent HCV-infection after liver transplantation (OLTX): Achievement of HCV eradication under antiviral treatment is associated with a strong, multispecific CD8+ T cell response. Hepatology 2002;36;4;220A

8. Vortrag auf der Tagung der “European Association for the Study of Liver Disease“in Berlin 2004:
Gruener NH, Ulsenheimer A, Jung MC, Gerlach JT, Zachoval R, Diepolder HM, Baretton G, Schauer R, Pape GR, Schirren CA. Analysis of a successful HCV-specific CD8+ T cell response in patients with recurrent HCV-infection after liver transplantation. J Hepatol 2004;40;6